Cephalopod Studies for Human Wellbeing

DWhatley

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More homeopathic than collection of large studies but interesting

Squid ink and its pharmacological activities
Jismi Jose, Krishnakumar K, Dineshkumar B

Abstract With the development of technical instruments the isolation and characterization of many natural products from marine and freshwater organisms, promotes a major advancement of discovery of these aquatic derived compounds. Due to the increasing demand of medicines from natural products, many researches on marine products are going on and is still a undiscovered journey. One such product is squid ink obtained from squid fish which is present in Mediterranean and Atlantic Ocean. It is mainly contained of melanin and many degradation studies have proven and still for the research work. The squid ink has spectacular activities in many ailments like uterine dysfunction, anticancer activity, antimicrobial activity, anti-inflammatory activity along with hypertensive effects. It has a very special place in homeopathic medicine and in traditional Chinese medicine due to its therapeutic uses. Hence it is believed that the squid ink can be used as a better tool against these dysfunctions. The present review aims to assemble various pharmacological activities of squid ink although deeper insight in its pharmacological potential is required.
 

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Quantitative Measurements of Octopus vulgaris Arms for Bioinspired Soft Robotics
Barbara Mazzolai, Laura Margheri, Cecilia Laschi 2019 (subscription)

Abstract
Bioinspiration is a popular trend in robotics research. Bioinspired design needs a deep knowledge of the selected biological model in order to extract the key features relevant to the design of the robot system. The octopus is an ideal model for soft robotics and has served as inspiration for the development of octopus-like robots and robot arms. The muscular hydrostat that composes the octopus arms is one of the key principles to imitate from the octopus, as well as the arm suckers. An engineering analysis and measurements is required, especially to understand the dimensions of deformations, the stiffness variability, the forces applied, the working principles of reaching and adhesion. We developed methods for measuring the octopus arm in vivo and we measured elongation and shortening, pulling force, stiffening, and morphology, quantitatively. The resulting data were used to create novel design principles and specifications used in developing new soft robots.
 

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Cuttlefish ink found promising for cancer treatment
by Lisa Zyga , Phys.org

Researchers have found that cuttlefish ink—a black suspension sprayed by cuttlefish to deter predators—contains nanoparticles that strongly inhibit the growth of cancerous tumors in mice. The nanoparticles consist mostly of melanin by weight, along with amino acids, monosaccharides (simple sugars), metals, and other compounds. The researchers showed that the nanoparticles modify the immune function in tumors, and when combined with irradiation, can almost completely inhibit tumor growth.
...
 

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Synthetic Squid Can Save You From Sunburn by Aria Bracci 2019

There’s nothing worse than a sunburn. Actually, there is—the potential damage that sunscreen can do to our bodies and the environment.

So would you try a natural alternative? While lots of products are labeled “organic,” a new method of concocting sunscreen gives a whole other meaning to “natural”: modeling it after the built-in UV protection in squid.
...
 

DWhatley

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Cytotoxic Effect of Ink Extracted from Cephalopoda on Cancer Cell Line
Israa H. Khudair, Balsam A. Hanna, Dhamia K. Sugar

ABSTRACT Objectives: The present study describes the biochemical, antioxidant and anticancer properties of the crude and melanin free ink of Sepia which is rich in both organic and inorganic components. Methods: The specimens of Sepia sp. were collected from Fao, South of Basrah /Iraq during November and December of 2018. They held the collected animals ventrally and squeezed the animal's posterior end to eject ink. The extracted ink samples both crude and melanin free ink were lyophilized, weighed and stored at 4°C until use .Then determination of the moisture, ash, total protein, lipid and carbohydrate in samples. The activity of ink as antioxidant was determination by the DPPH method. Finally, evaluation of anticancer activity by the MTT assay. Results: The quantitative analysis define the presence of protein (1.1 – 1.3 mg/ml), lipid (1.38 – 1.48 mg/ml), carbohydrates (0.01 –0.9mg/ml), ash (14and5%) and moisture (91.7-83.75 %) content.. The ink revealed good antioxidant activity, thereby lowering or retarding the initiation of lipid oxidation process. The ink was screened for its anticancer activity against human breast adenocarcinoma cell line (MCF 7) and it exhibited a strong cytotoxicity by inhibiting the cell growth. Conclusion: Thus the ink, especially the melanin free ink is known to possess significant potent antioxidant activity and anti-proliferative effect. The present study showed that the melanin free ink was richer in biochemical properties than the crude ink
 

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